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Assay Detail

CHEMBL931785

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Functional
Antiproliferative activity against human NCI-H460 cells after 72 hrs by trypan blue test
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of pyrroloiminoquinone derivatives.
Passarella D, Belinghieri F, Scarpellini M, Pratesi G, Zunino F, Gia OM, Via LD, Santoro G, Danieli B.
Bioorg Med Chem (2008) 16 : 2431 -2438
PubMed 18077173 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.45 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.55
CHEMBL403518 1 6.02
CHEMBL402544 1 5.67
CHEMBL403721 1 5.26
CHEMBL270669 1 5.21
CHEMBL272647 1 5.11
CHEMBL410262 1 5.06
CHEMBL408864 1 5.05
CHEMBL272373 MAKALUVAMINE K 1 4.97
CHEMBL270016 1 4.64
CHEMBL272371 1 -
CHEMBL272372 1 -
CHEMBL404920 1 -
CHEMBL271961 1 -
CHEMBL272429 1 -
CHEMBL407745 1 -
CHEMBL408866 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 28.0 nM 7.55
CHEMBL403518 IC50 = 960.0 nM 6.02
CHEMBL402544 IC50 = 2120.0 nM 5.67
CHEMBL403721 IC50 = 5500.0 nM 5.26
CHEMBL270669 IC50 = 6200.0 nM 5.21
CHEMBL272647 IC50 = 7700.0 nM 5.11
CHEMBL410262 IC50 = 8800.0 nM 5.06
CHEMBL408864 IC50 = 9000.0 nM 5.05
CHEMBL272373 MAKALUVAMINE K IC50 = 10800.0 nM 4.97
CHEMBL270016 IC50 = 23000.0 nM 4.64
CHEMBL272371 IC50 > 40000.0 nM -
CHEMBL272372 IC50 > 40000.0 nM -
CHEMBL404920 IC50 > 40000.0 nM -
CHEMBL271961 IC50 > 60000.0 nM -
CHEMBL272429 IC50 > 60000.0 nM -
CHEMBL407745 IC50 > 60000.0 nM -
CHEMBL408866 IC50 > 60000.0 nM -