Assay Detail
Functional
CHEMBL931808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant PPARgamma in HEK293 cells by GAL4 transactivation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.61 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402840 | — | — | 1 | 7.37 |
| CHEMBL270664 | — | — | 1 | 7.30 |
| CHEMBL402841 | — | — | 1 | 7.16 |
| CHEMBL272137 | — | — | 1 | 7.08 |
| CHEMBL270451 | — | — | 1 | 6.92 |
| CHEMBL402161 | — | — | 1 | 6.92 |
| CHEMBL270801 | — | — | 1 | 6.66 |
| CHEMBL270665 | — | — | 1 | 6.55 |
| CHEMBL270587 | — | — | 1 | 6.50 |
| CHEMBL255426 | — | — | 1 | 6.21 |
| CHEMBL271877 | — | — | 1 | 5.64 |
| CHEMBL255392 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402840 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL270664 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL402841 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL272137 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL270451 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL402161 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL270801 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL270665 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL270587 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL255426 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL271877 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL255392 | — | EC50 | = | 9400.0 | nM | 5.03 |