Assay Detail

CHEMBL931897

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against RSV CI57 replication in HeLa cells

ChEMBL ↗

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Target

Respiratory syncytial virus (CHEMBL612679) ↗

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Primary target Respiratory syncytial virus

CHEMBL612679

Anchored from Assay target.

Protein identity Respiratory syncytial virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Respiratory syncytial virus
Cell Type	HeLa
Confidence	1 — Organism
Curated By	Intermediate

Target

Respiratory syncytial virus (CHEMBL612679) ↗

Type	ORGANISM
Organism	Respiratory syncytial virus

Publication

Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).

Bonfanti JF, Meyer C, Doublet F, Fortin J, Muller P, Queguiner L, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, van Remoortere P, Janssens F, Wigerinck P, Andries K.
J Med Chem (2008) 51 : 875 -896
PubMed 18254606 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	10.10	10.10
pEC90	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL408963	—	—	3	10.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL408963	—	EC50	=	0.07943	nM	10.10
CHEMBL408963	—	EC50	=	4e-05	ug.mL-1	-
CHEMBL408963	—	pEC90	=	9.8	—	-