Assay Detail
Functional
CHEMBL931912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MCF7 cells after 48 hrs by MTS assay
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor effects of curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.50 | 5.15 |
| IC70 | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272717 | — | — | 2 | 5.15 |
| CHEMBL181529 | — | — | 2 | 4.88 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 4.53 |
| CHEMBL256593 | — | — | 2 | 4.44 |
| CHEMBL256436 | — | — | 2 | 4.30 |
| CHEMBL255373 | — | — | 2 | 4.15 |
| CHEMBL273154 | — | — | 2 | 4.03 |
| CHEMBL256640 | — | — | 2 | - |
| CHEMBL255571 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272717 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL181529 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL140 | CURCUMIN | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL256593 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL256436 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL255373 | — | IC50 | = | 70300.0 | nM | 4.15 |
| CHEMBL273154 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL140 | CURCUMIN | IC70 | = | 51.7 | uM | - |
| CHEMBL256593 | — | IC70 | = | 43.4 | uM | - |
| CHEMBL272717 | — | IC70 | = | 9.2 | uM | - |
| CHEMBL181529 | — | IC70 | = | 23.2 | uM | - |
| CHEMBL256640 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL256640 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL256436 | — | IC70 | = | 68.1 | uM | - |
| CHEMBL273154 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL255571 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL255571 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL255373 | — | IC70 | = | 93.5 | uM | - |