Assay Detail
Functional
CHEMBL931913
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Growth inhibition of human multidrug-resistant MCF7R cells after 48 hrs by MTS assay
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor effects of curcumin and structurally beta-diketone modified analogs on multidrug resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.52 | 5.03 |
| IC70 | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272717 | — | — | 2 | 5.03 |
| CHEMBL181529 | — | — | 2 | 4.92 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 4.58 |
| CHEMBL256593 | — | — | 2 | 4.41 |
| CHEMBL255373 | — | — | 2 | 4.30 |
| CHEMBL256436 | — | — | 2 | 4.26 |
| CHEMBL273154 | — | — | 2 | 4.17 |
| CHEMBL256640 | — | — | 2 | - |
| CHEMBL255571 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272717 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL181529 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL140 | CURCUMIN | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL256593 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL255373 | — | IC50 | = | 49800.0 | nM | 4.30 |
| CHEMBL256436 | — | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL273154 | — | IC50 | = | 67600.0 | nM | 4.17 |
| CHEMBL140 | CURCUMIN | IC70 | = | 46.2 | uM | - |
| CHEMBL256593 | — | IC70 | = | 52.8 | uM | - |
| CHEMBL272717 | — | IC70 | = | 12.9 | uM | - |
| CHEMBL181529 | — | IC70 | = | 24.7 | uM | - |
| CHEMBL255373 | — | IC70 | = | 79.5 | uM | - |
| CHEMBL256640 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL256640 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL256436 | — | IC70 | = | 81.8 | uM | - |
| CHEMBL255571 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL255571 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL273154 | — | IC70 | = | 88.8 | uM | - |