Assay Detail
Binding
CHEMBL931917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PGE2 from human EP2 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.66 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.31 |
| CHEMBL272277 | — | — | 1 | 7.68 |
| CHEMBL257217 | — | — | 1 | 7.27 |
| CHEMBL271896 | BUTAPROST | 2.0 | 1 | 6.96 |
| CHEMBL222715 | — | — | 1 | 6.92 |
| CHEMBL257658 | — | — | 1 | 6.85 |
| CHEMBL251294 | — | — | 1 | 6.37 |
| CHEMBL258332 | — | — | 1 | 6.00 |
| CHEMBL272276 | — | — | 1 | 5.59 |
| CHEMBL271488 | — | — | 1 | 4.60 |
| CHEMBL272969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL272277 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL257217 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL271896 | BUTAPROST | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL222715 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL257658 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL251294 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL258332 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL272276 | — | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL271488 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL272969 | — | Ki | > | 10000.0 | nM | - |