Assay Detail
Functional
CHEMBL931918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human EP2 receptor by cAMP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.35 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272277 | — | — | 1 | 8.52 |
| CHEMBL222715 | — | — | 1 | 7.82 |
| CHEMBL257658 | — | — | 1 | 7.72 |
| CHEMBL251294 | — | — | 1 | 7.10 |
| CHEMBL258332 | — | — | 1 | 6.60 |
| CHEMBL272276 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272277 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL222715 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL257658 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL251294 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL258332 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL272276 | — | EC50 | = | 434.0 | nM | 6.36 |