Assay Detail
Binding
CHEMBL931943
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Inhibition of AmpC beta-lactamase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.98 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402221 | — | — | 1 | 9.21 |
| CHEMBL270810 | — | — | 1 | 8.85 |
| CHEMBL271238 | — | — | 1 | 8.82 |
| CHEMBL122450 | — | — | 1 | 8.68 |
| CHEMBL272130 | — | — | 1 | 8.40 |
| CHEMBL1744422 | — | — | 1 | 8.40 |
| CHEMBL401578 | — | — | 1 | 8.26 |
| CHEMBL403677 | — | — | 1 | 7.80 |
| CHEMBL271723 | — | — | 1 | 7.28 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402221 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL270810 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL271238 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL122450 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL272130 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1744422 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL401578 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL403677 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL271723 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 84000.0 | nM | 4.08 |