Assay Detail
Binding
CHEMBL931950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to pig cortical membrane dopamine D1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.37 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272073 | — | — | 1 | 5.85 |
| CHEMBL271513 | — | — | 1 | 5.47 |
| CHEMBL256637 | — | — | 1 | 5.46 |
| CHEMBL255163 | — | — | 1 | 5.29 |
| CHEMBL270408 | — | — | 1 | 5.28 |
| CHEMBL256492 | — | — | 1 | 5.27 |
| CHEMBL310843 | — | — | 1 | 5.26 |
| CHEMBL404888 | — | — | 1 | 5.24 |
| CHEMBL270406 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272073 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL271513 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL256637 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL255163 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL270408 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL256492 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL310843 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL404888 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL270406 | — | Ki | = | 6800.0 | nM | 5.17 |