Assay Detail
Binding
CHEMBL931952
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Displacement of [3H]prazosin from pig cortical membrane adrenergic alpha-1 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.39 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256637 | — | — | 1 | 8.36 |
| CHEMBL270406 | — | — | 1 | 7.89 |
| CHEMBL404888 | — | — | 1 | 7.75 |
| CHEMBL256492 | — | — | 1 | 7.68 |
| CHEMBL270408 | — | — | 1 | 7.44 |
| CHEMBL271513 | — | — | 1 | 7.33 |
| CHEMBL272073 | — | — | 1 | 6.80 |
| CHEMBL255163 | — | — | 1 | 6.72 |
| CHEMBL310843 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256637 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL270406 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL404888 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL256492 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL270408 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL271513 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL272073 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL255163 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL310843 | — | Ki | = | 270.0 | nM | 6.57 |