Assay Detail
Binding
CHEMBL931956
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Binding affinity to human dopamine D4.4 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.12 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270406 | — | — | 1 | 8.89 |
| CHEMBL270408 | — | — | 1 | 8.80 |
| CHEMBL256637 | — | — | 1 | 8.77 |
| CHEMBL256492 | — | — | 1 | 8.74 |
| CHEMBL310843 | — | — | 1 | 8.66 |
| CHEMBL271513 | — | — | 1 | 8.43 |
| CHEMBL404888 | — | — | 1 | 7.92 |
| CHEMBL272073 | — | — | 1 | 7.30 |
| CHEMBL255163 | — | — | 1 | 7.09 |
| CHEMBL404570 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270406 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL270408 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL256637 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL256492 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL310843 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL271513 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL404888 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL272073 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL255163 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL404570 | — | Ki | = | 250.0 | nM | 6.60 |