Assay Detail
Functional
CHEMBL932019
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Vasorelaxation activity in PGF2-alpha-precontracted pig pulmonary artery
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.09 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6622 | ISOSORBIDE DINITRATE | 4.0 | 1 | 6.38 |
| CHEMBL269865 | — | — | 1 | 5.43 |
| CHEMBL407320 | — | — | 1 | 5.06 |
| CHEMBL271746 | — | — | 1 | 4.98 |
| CHEMBL273051 | — | — | 1 | 4.65 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6622 | ISOSORBIDE DINITRATE | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL269865 | — | EC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL407320 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL271746 | — | EC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL273051 | — | EC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL95 | TACRINE | EC50 | = | 97300.0 | nM | 4.01 |