Assay Detail
Binding
CHEMBL932209
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Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.80 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285436 | — | — | 1 | 8.14 |
| CHEMBL286862 | — | — | 1 | 8.12 |
| CHEMBL34016 | — | — | 1 | 8.11 |
| CHEMBL285962 | — | — | 1 | 8.10 |
| CHEMBL34526 | — | — | 1 | 8.09 |
| CHEMBL432083 | — | — | 1 | 8.08 |
| CHEMBL284694 | — | — | 1 | 8.08 |
| CHEMBL34546 | — | — | 1 | 8.07 |
| CHEMBL286449 | — | — | 1 | 8.06 |
| CHEMBL287145 | — | — | 1 | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.99 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285436 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL286862 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL34016 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL285962 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL34526 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL432083 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL284694 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL34546 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL286449 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL287145 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL310671 | SACCHARIN | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 294.0 | nM | 6.53 |