Assay Detail
Binding
CHEMBL932239
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Inhibition of human neutrophil elastase
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.02 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285231 | — | — | 1 | 10.60 |
| CHEMBL403098 | — | — | 1 | 10.22 |
| CHEMBL334978 | — | — | 1 | 10.00 |
| CHEMBL270680 | — | — | 1 | 9.70 |
| CHEMBL336779 | — | — | 1 | 9.70 |
| CHEMBL127714 | — | — | 1 | 9.48 |
| CHEMBL262516 | — | — | 1 | 9.47 |
| CHEMBL404910 | — | — | 1 | 9.46 |
| CHEMBL24058 | — | — | 1 | 9.31 |
| CHEMBL277672 | — | — | 1 | 9.28 |
| CHEMBL354832 | — | — | 1 | 9.22 |
| CHEMBL283168 | — | — | 1 | 9.19 |
| CHEMBL256466 | — | — | 1 | 9.18 |
| CHEMBL404871 | — | — | 1 | 9.09 |
| CHEMBL406200 | — | — | 1 | 8.89 |
| CHEMBL278134 | — | — | 1 | 8.85 |
| CHEMBL354883 | — | — | 1 | 8.80 |
| CHEMBL338651 | — | — | 1 | 8.64 |
| CHEMBL108783 | — | — | 1 | 8.52 |
| CHEMBL23234 | — | — | 1 | 8.44 |
| CHEMBL270651 | — | — | 1 | 8.19 |
| CHEMBL282705 | — | — | 1 | 8.19 |
| CHEMBL128410 | — | — | 1 | 7.96 |
| CHEMBL25892 | FRESELESTAT | 2.0 | 1 | 7.92 |
| CHEMBL353441 | — | — | 1 | 7.60 |
| CHEMBL352305 | — | — | 1 | 7.55 |
| CHEMBL165525 | — | — | 1 | 7.39 |
| CHEMBL438709 | — | — | 1 | 7.14 |
| CHEMBL169842 | — | — | 1 | 6.57 |
| CHEMBL167824 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285231 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL403098 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL334978 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL270680 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL336779 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL127714 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL262516 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL404910 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL24058 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL277672 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL354832 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL283168 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL256466 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL404871 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL406200 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL278134 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL354883 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL338651 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL108783 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL23234 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL270651 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL282705 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL128410 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL25892 | FRESELESTAT | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL353441 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL352305 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL165525 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL438709 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL169842 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL167824 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL168761 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL355477 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL169076 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL257889 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL168834 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL169750 | — | Ki | = | 80000.0 | nM | 4.10 |