Assay Detail
Binding
CHEMBL932336
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Inhibition of EphB4
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.74 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257553 | — | — | 1 | 7.40 |
| CHEMBL445162 | — | — | 1 | 7.05 |
| CHEMBL256725 | — | — | 1 | 6.62 |
| CHEMBL256348 | — | — | 1 | 6.52 |
| CHEMBL169186 | — | — | 1 | 6.46 |
| CHEMBL404444 | — | — | 1 | 6.34 |
| CHEMBL254588 | — | — | 1 | 6.26 |
| CHEMBL255874 | — | — | 1 | 6.24 |
| CHEMBL258016 | — | — | 1 | 6.20 |
| CHEMBL402903 | — | — | 1 | 6.19 |
| CHEMBL255875 | — | — | 1 | 6.00 |
| CHEMBL256724 | — | — | 1 | 5.94 |
| CHEMBL258435 | — | — | 1 | 5.90 |
| CHEMBL401907 | — | — | 1 | 5.88 |
| CHEMBL402934 | — | — | 1 | 5.81 |
| CHEMBL404445 | — | — | 1 | 5.80 |
| CHEMBL257576 | — | — | 1 | 5.71 |
| CHEMBL402584 | — | — | 1 | 5.64 |
| CHEMBL253741 | — | — | 1 | 5.59 |
| CHEMBL403672 | — | — | 1 | 5.53 |
| CHEMBL253957 | — | — | 1 | 5.41 |
| CHEMBL402933 | — | — | 1 | 5.30 |
| CHEMBL255947 | — | — | 1 | 5.22 |
| CHEMBL257771 | — | — | 1 | 5.11 |
| CHEMBL255949 | — | — | 1 | 4.95 |
| CHEMBL254157 | — | — | 1 | 4.86 |
| CHEMBL403673 | — | — | 1 | 4.80 |
| CHEMBL428067 | — | — | 1 | 4.69 |
| CHEMBL403614 | — | — | 1 | 4.45 |
| CHEMBL404178 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257553 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL445162 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL256725 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL256348 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL169186 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL404444 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL254588 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL255874 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL258016 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL402903 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL255875 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL256724 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL258435 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL401907 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL402934 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL404445 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL257576 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL402584 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL253741 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL403672 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL253957 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL402933 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL255947 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL257771 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL255949 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL254157 | — | IC50 | = | 13960.0 | nM | 4.86 |
| CHEMBL403673 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL428067 | — | IC50 | = | 20490.0 | nM | 4.69 |
| CHEMBL403614 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL404178 | — | IC50 | = | 41000.0 | nM | 4.39 |