Assay Detail
Binding
CHEMBL932361
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Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 7.90 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403898 | — | — | 1 | 9.01 |
| CHEMBL258388 | — | — | 1 | 9.01 |
| CHEMBL257779 | — | — | 1 | 9.01 |
| CHEMBL256298 | — | — | 1 | 9.00 |
| CHEMBL401909 | — | — | 1 | 8.89 |
| CHEMBL403811 | — | — | 1 | 8.89 |
| CHEMBL257601 | — | — | 1 | 8.85 |
| CHEMBL401883 | — | — | 1 | 8.72 |
| CHEMBL401908 | — | — | 1 | 8.70 |
| CHEMBL401884 | — | — | 1 | 8.64 |
| CHEMBL256986 | — | — | 1 | 8.59 |
| CHEMBL401975 | — | — | 1 | 8.57 |
| CHEMBL258389 | — | — | 1 | 8.54 |
| CHEMBL257129 | — | — | 1 | 8.54 |
| CHEMBL256158 | — | — | 1 | 8.51 |
| CHEMBL402737 | — | — | 1 | 8.44 |
| CHEMBL257963 | — | — | 1 | 8.41 |
| CHEMBL257752 | — | — | 1 | 8.37 |
| CHEMBL401830 | — | — | 1 | 8.34 |
| CHEMBL401988 | — | — | 1 | 8.28 |
| CHEMBL404638 | — | — | 1 | 8.24 |
| CHEMBL428951 | — | — | 1 | 8.11 |
| CHEMBL403758 | — | — | 1 | 8.05 |
| CHEMBL257985 | — | — | 1 | 7.92 |
| CHEMBL258165 | — | — | 1 | 7.89 |
| CHEMBL403944 | — | — | 1 | 7.82 |
| CHEMBL257364 | — | — | 1 | 7.70 |
| CHEMBL404564 | — | — | 1 | 7.68 |
| CHEMBL403369 | — | — | 1 | 7.58 |
| CHEMBL253953 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403898 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL257779 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL258388 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL256298 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL401909 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL403811 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL257601 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL401883 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL401908 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL401884 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL256986 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL401975 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL258389 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL257129 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL256158 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL402737 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL257963 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL257752 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL401830 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL401988 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL404638 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL428951 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL403758 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL257985 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL258165 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403944 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL257364 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL404564 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL403369 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL253953 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL254993 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL404743 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL253955 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL254790 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL257962 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL403549 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL403589 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL404173 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL402302 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL404880 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL429318 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL428429 | FIG 1 | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL428430 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL258217 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL403384 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL403165 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL403687 | — | IC50 | = | 963.0 | nM | 6.02 |
| CHEMBL257753 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL257754 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL254789 | — | IC50 | < | 1.0 | nM | - |