Assay Detail
Binding
CHEMBL932362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 7.49 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403898 | — | — | 1 | 8.92 |
| CHEMBL257779 | — | — | 1 | 8.89 |
| CHEMBL401883 | — | — | 1 | 8.72 |
| CHEMBL257601 | — | — | 1 | 8.64 |
| CHEMBL401884 | — | — | 1 | 8.64 |
| CHEMBL257752 | — | — | 1 | 8.55 |
| CHEMBL401988 | — | — | 1 | 8.54 |
| CHEMBL401909 | — | — | 1 | 8.35 |
| CHEMBL404743 | — | — | 1 | 8.19 |
| CHEMBL257963 | — | — | 1 | 8.18 |
| CHEMBL258388 | — | — | 1 | 8.15 |
| CHEMBL256298 | — | — | 1 | 8.10 |
| CHEMBL254993 | — | — | 1 | 8.08 |
| CHEMBL256158 | — | — | 1 | 8.07 |
| CHEMBL257129 | — | — | 1 | 8.01 |
| CHEMBL428951 | — | — | 1 | 8.00 |
| CHEMBL403758 | — | — | 1 | 8.00 |
| CHEMBL254790 | — | — | 1 | 7.96 |
| CHEMBL403811 | — | — | 1 | 7.96 |
| CHEMBL401908 | — | — | 1 | 7.92 |
| CHEMBL403369 | — | — | 1 | 7.82 |
| CHEMBL402302 | — | — | 1 | 7.72 |
| CHEMBL401975 | — | — | 1 | 7.70 |
| CHEMBL258389 | — | — | 1 | 7.66 |
| CHEMBL402737 | — | — | 1 | 7.66 |
| CHEMBL428429 | FIG 1 | — | 1 | 7.43 |
| CHEMBL256986 | — | — | 1 | 7.38 |
| CHEMBL401830 | — | — | 1 | 7.34 |
| CHEMBL258217 | — | — | 1 | 7.27 |
| CHEMBL403384 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403898 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL257779 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL401883 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL257601 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL401884 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL257752 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL401988 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL401909 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL404743 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL257963 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL258388 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL256298 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL254993 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL256158 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL257129 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL428951 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL403758 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL254790 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL403811 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL401908 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL403369 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL402302 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL401975 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL258389 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL402737 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL428429 | FIG 1 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL256986 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL401830 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL258217 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL403384 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL404638 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL404564 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL257985 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL403944 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL253953 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL258165 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL404173 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL257364 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL403549 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL253955 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL403687 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL428430 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL429318 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL404880 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL257962 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL403165 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL403589 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL257754 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL257753 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL254789 | — | IC50 | < | 1.0 | nM | - |