Assay Detail
Binding
CHEMBL932639
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Inhibition of GSK3-beta in human U87MG cells by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | U-87MG ATCC |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.05 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260000 | — | — | 1 | 6.35 |
| CHEMBL406863 | — | — | 1 | 6.23 |
| CHEMBL260577 | — | — | 1 | 6.23 |
| CHEMBL405384 | — | — | 1 | 6.23 |
| CHEMBL263664 | — | — | 1 | 6.18 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.09 |
| CHEMBL259998 | — | — | 1 | - |
| CHEMBL260463 | — | — | 1 | - |
| CHEMBL259999 | — | — | 1 | - |
| CHEMBL407504 | — | — | 1 | - |
| CHEMBL409503 | — | — | 1 | - |
| CHEMBL260358 | — | — | 1 | - |
| CHEMBL261034 | — | — | 1 | - |
| CHEMBL261247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260000 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL406863 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL260577 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL405384 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL263664 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL98350 | LY-294002 | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL259998 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL260463 | — | IC50 | - | — | - | |
| CHEMBL259999 | — | IC50 | - | — | - | |
| CHEMBL407504 | — | IC50 | - | — | - | |
| CHEMBL409503 | — | IC50 | - | — | - | |
| CHEMBL260358 | — | IC50 | - | — | - | |
| CHEMBL261034 | — | IC50 | - | — | - | |
| CHEMBL261247 | — | IC50 | - | — | - |