Assay Detail
Binding
CHEMBL932801
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Inhibition of [3H]spermidine uptake at PAT in mouse L1210 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.55 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541654 | — | — | 1 | 6.77 |
| CHEMBL558186 | — | — | 1 | 6.41 |
| CHEMBL536770 | — | — | 1 | 6.31 |
| CHEMBL557403 | — | — | 1 | 6.28 |
| CHEMBL540552 | — | — | 1 | 5.75 |
| CHEMBL537020 | — | — | 1 | 5.58 |
| CHEMBL540336 | — | — | 1 | 5.42 |
| CHEMBL542262 | — | — | 1 | 5.35 |
| CHEMBL536774 | — | — | 1 | 5.22 |
| CHEMBL557794 | — | — | 1 | 4.91 |
| CHEMBL558390 | — | — | 1 | 4.49 |
| CHEMBL3216421 | — | — | 1 | 4.12 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541654 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL558186 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL536770 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL557403 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL540552 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL537020 | — | Ki | = | 2660.0 | nM | 5.58 |
| CHEMBL540336 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL542262 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL536774 | — | Ki | = | 5970.0 | nM | 5.22 |
| CHEMBL557794 | — | Ki | = | 12400.0 | nM | 4.91 |
| CHEMBL558390 | — | Ki | = | 32200.0 | nM | 4.49 |
| CHEMBL3216421 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL515 | CHLORAMBUCIL | Ki | > | 150000.0 | nM | - |