Assay Detail
Functional
CHEMBL932802
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Cytotoxicity against mouse L1210 cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.60 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557403 | — | — | 1 | 6.80 |
| CHEMBL541654 | — | — | 1 | 6.60 |
| CHEMBL540552 | — | — | 1 | 6.52 |
| CHEMBL540336 | — | — | 1 | 6.30 |
| CHEMBL558186 | — | — | 1 | 6.11 |
| CHEMBL3216421 | — | — | 1 | 5.66 |
| CHEMBL558390 | — | — | 1 | 5.20 |
| CHEMBL537020 | — | — | 1 | 5.18 |
| CHEMBL557794 | — | — | 1 | 5.09 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 4.85 |
| CHEMBL536774 | — | — | 1 | 4.45 |
| CHEMBL542262 | — | — | 1 | 4.44 |
| CHEMBL536770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557403 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL541654 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL540552 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL540336 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL558186 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3216421 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL558390 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL537020 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL557794 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL536774 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL542262 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL536770 | — | IC50 | = | 122300.0 | nM | - |