Assay Detail
Functional
CHEMBL932803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse L1210 cells in presence of ODC inhibitor difluoromethylornithine
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.97 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540552 | — | — | 1 | 7.05 |
| CHEMBL558186 | — | — | 1 | 6.66 |
| CHEMBL557403 | — | — | 1 | 6.44 |
| CHEMBL540336 | — | — | 1 | 6.37 |
| CHEMBL558390 | — | — | 1 | 5.01 |
| CHEMBL536770 | — | — | 1 | 4.31 |
| CHEMBL542262 | — | — | 1 | - |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
| CHEMBL3216421 | — | — | 1 | - |
| CHEMBL537020 | — | — | 1 | - |
| CHEMBL557794 | — | — | 1 | - |
| CHEMBL536774 | — | — | 1 | - |
| CHEMBL541654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540552 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL558186 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL557403 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL540336 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL558390 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL536770 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL542262 | — | IC50 | - | — | - | |
| CHEMBL515 | CHLORAMBUCIL | IC50 | - | — | - | |
| CHEMBL3216421 | — | IC50 | - | — | - | |
| CHEMBL537020 | — | IC50 | - | — | - | |
| CHEMBL557794 | — | IC50 | - | — | - | |
| CHEMBL536774 | — | IC50 | - | — | - | |
| CHEMBL541654 | — | IC50 | - | — | - |