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Assay Detail

CHEMBL932831

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effect on quorum sensing in Candida albicans assessed as inhibition of germ tube formation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Candida albicans
Confidence 1 — Organism
Curated By Intermediate

Target

Candida albicans (CHEMBL366)
Type ORGANISM
Organism Candida albicans

Publication

Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans.
Shchepin R, Navarathna DH, Dumitru R, Lippold S, Nickerson KW, Dussault PH.
Bioorg Med Chem (2008) 16 : 1842 -1848
PubMed 18037299 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.50 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25308 FARNESOL 1 6.00
CHEMBL401887 1 6.00
CHEMBL256215 1 6.00
CHEMBL258289 1 5.52
CHEMBL270615 1 5.52
CHEMBL428871 1 5.30
CHEMBL255150 1 5.16
CHEMBL404704 1 5.00
CHEMBL403963 1 5.00
CHEMBL273178 1 -
CHEMBL255588 1 -
CHEMBL404113 1 -
CHEMBL255149 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25308 FARNESOL IC50 = 1000.0 nM 6.00
CHEMBL401887 IC50 = 1000.0 nM 6.00
CHEMBL256215 IC50 = 1000.0 nM 6.00
CHEMBL258289 IC50 = 3000.0 nM 5.52
CHEMBL270615 IC50 = 3000.0 nM 5.52
CHEMBL428871 IC50 = 5000.0 nM 5.30
CHEMBL255150 IC50 = 7000.0 nM 5.16
CHEMBL404704 IC50 = 10000.0 nM 5.00
CHEMBL403963 IC50 = 10000.0 nM 5.00
CHEMBL273178 IC50 > 50000.0 nM -
CHEMBL255588 IC50 > 50000.0 nM -
CHEMBL404113 IC50 > 50000.0 nM -
CHEMBL255149 IC50 >= 100000.0 nM -