Assay Detail
Binding
CHEMBL932857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S]TBPS from GABAA receptor in rat brain membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259246 | — | — | 1 | 7.40 |
| CHEMBL271371 | — | — | 1 | 7.22 |
| CHEMBL429756 | — | — | 1 | 6.96 |
| CHEMBL406188 | — | — | 1 | 6.60 |
| CHEMBL87285 | ANDROSTERONE | — | 1 | 6.39 |
| CHEMBL271599 | — | — | 1 | 5.93 |
| CHEMBL272037 | — | — | 1 | 5.84 |
| CHEMBL258825 | — | — | 1 | 5.80 |
| CHEMBL211898 | — | — | 1 | 5.38 |
| CHEMBL379925 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259246 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL271371 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL429756 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL406188 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL87285 | ANDROSTERONE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL271599 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL272037 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL258825 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL211898 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL379925 | — | IC50 | = | 5010.0 | nM | 5.30 |