Assay Detail
Binding
CHEMBL932865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat GABAA alpha-1-beta-2-gamma-2L receptor expressed in HEK293 cells assessed as macroscopic current amplitude by electrophysiological method
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 3 | 6.41 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259246 | — | — | 2 | 6.47 |
| CHEMBL271371 | — | — | 2 | 6.39 |
| CHEMBL429756 | — | — | 2 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259246 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL271371 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL429756 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL429756 | — | Activity | = | 269.0 | % | - |
| CHEMBL271371 | — | Activity | = | 294.0 | % | - |
| CHEMBL259246 | — | Activity | = | 262.0 | % | - |