Assay Detail
Functional
CHEMBL932952
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Cytotoxicity against human SJSA1 cells expressing GRP78 after 6 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.55 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401978 | — | — | 1 | 8.96 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.49 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401978 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6.2 | nM | 8.21 |