Assay Detail
Binding
CHEMBL933038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ACE2 by fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.61 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271225 | — | — | 1 | 8.85 |
| CHEMBL257726 | — | — | 1 | 8.85 |
| CHEMBL269997 | — | — | 1 | 8.82 |
| CHEMBL252391 | — | — | 1 | 8.82 |
| CHEMBL269996 | — | — | 1 | 8.80 |
| CHEMBL257270 | — | — | 1 | 8.74 |
| CHEMBL404117 | — | — | 1 | 8.74 |
| CHEMBL257229 | — | — | 1 | 8.62 |
| CHEMBL257727 | — | — | 1 | 8.16 |
| CHEMBL271223 | — | — | 1 | 8.15 |
| CHEMBL257026 | — | — | 1 | 7.19 |
| CHEMBL437595 | — | — | 1 | 7.08 |
| CHEMBL350414 | — | — | 1 | 7.07 |
| CHEMBL258333 | — | — | 1 | 6.50 |
| CHEMBL271224 | — | — | 1 | 6.38 |
| CHEMBL272925 | — | — | 1 | 6.26 |
| CHEMBL402987 | — | — | 1 | 6.07 |
| CHEMBL163454 | — | — | 1 | 5.85 |
| CHEMBL404044 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271225 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL257726 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL269997 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL252391 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL269996 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL257270 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL404117 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL257229 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL257727 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL271223 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL257026 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL437595 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL350414 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL258333 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL271224 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL272925 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL402987 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL163454 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL404044 | — | Ki | = | 2300.0 | nM | 5.64 |