Assay Detail
Functional
CHEMBL933110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human EP4 receptor by cAMP assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.81 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222715 | — | — | 1 | 10.70 |
| CHEMBL258332 | — | — | 1 | 10.52 |
| CHEMBL272276 | — | — | 1 | 10.52 |
| CHEMBL251294 | — | — | 1 | 10.40 |
| CHEMBL272277 | — | — | 1 | 9.52 |
| CHEMBL257658 | — | — | 1 | 8.52 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222715 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL258332 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL272276 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL251294 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL272277 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL257658 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL548 | DINOPROSTONE | EC50 | = | 3.0 | nM | 8.52 |