Assay Detail
Binding
CHEMBL933189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HIV1 integrase strand transfer activity
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 7.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410516 | — | — | 1 | 8.52 |
| CHEMBL272009 | — | — | 1 | 8.40 |
| CHEMBL260102 | — | — | 1 | 8.40 |
| CHEMBL270536 | — | — | 1 | 8.30 |
| CHEMBL279547 | — | — | 1 | 8.30 |
| CHEMBL271627 | — | — | 1 | 8.30 |
| CHEMBL270744 | — | — | 1 | 8.30 |
| CHEMBL406657 | — | — | 1 | 8.22 |
| CHEMBL269845 | — | — | 1 | 8.22 |
| CHEMBL412090 | — | — | 1 | 8.22 |
| CHEMBL412089 | — | — | 1 | 8.15 |
| CHEMBL272883 | — | — | 1 | 8.15 |
| CHEMBL412109 | — | — | 1 | 8.15 |
| CHEMBL270514 | — | — | 1 | 8.15 |
| CHEMBL272446 | — | — | 1 | 8.15 |
| CHEMBL408479 | — | — | 1 | 8.15 |
| CHEMBL272871 | — | — | 1 | 8.15 |
| CHEMBL406656 | — | — | 1 | 8.15 |
| CHEMBL272172 | — | — | 1 | 8.15 |
| CHEMBL271821 | — | — | 1 | 8.15 |
| CHEMBL259896 | — | — | 1 | 8.10 |
| CHEMBL405261 | — | — | 1 | 8.10 |
| CHEMBL271757 | — | — | 1 | 8.05 |
| CHEMBL269844 | — | — | 1 | 8.05 |
| CHEMBL408480 | — | — | 1 | 8.05 |
| CHEMBL411489 | — | — | 1 | 8.00 |
| CHEMBL216683 | — | — | 1 | 8.00 |
| CHEMBL271744 | — | — | 1 | 8.00 |
| CHEMBL270513 | — | — | 1 | 8.00 |
| CHEMBL271541 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410516 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL272009 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL260102 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL270536 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL279547 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL271627 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL270744 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL406657 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL269845 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL412090 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL272871 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL272883 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL412109 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL270514 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL272446 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL412089 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL408479 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL406656 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL272172 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL271821 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL259896 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL405261 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL271757 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL269844 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL408480 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL411489 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270513 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL216683 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL271744 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL271541 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL409932 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL408962 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL410850 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL270535 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL271743 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL259673 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL269873 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL259894 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL270552 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL429408 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL270308 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL259885 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL271629 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL386710 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL217566 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL260094 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL429583 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL409490 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL429737 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL216317 | — | IC50 | = | 100.0 | nM | 7.00 |