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Assay Detail

CHEMBL933193

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ERG by FLIPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Wang W, Devasthale P, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Kunselman L, Morgan N, Ponticiello R, Zebo R, Zhang L, Locke K, Lippy J, O'Malley K, Hosagrahara V, Zhang L, Kadiyala P, Chang C, Muckelbauer J, Doweyko AM, Zahler R, Ryono D, Hariharan N, Cheng PT.
Bioorg Med Chem Lett (2008) 18 : 1939 -1944
PubMed 18291645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.29 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL272336 1 5.89
CHEMBL429734 1 5.75
CHEMBL404646 1 5.68
CHEMBL257517 1 5.50
CHEMBL255389 1 5.21
CHEMBL256468 1 4.74
CHEMBL411118 1 4.27
CHEMBL271240 1 -
CHEMBL257891 1 -
CHEMBL272962 1 -
CHEMBL255388 1 -
CHEMBL271739 1 -
CHEMBL403847 1 -
CHEMBL404451 1 -
CHEMBL272963 1 -
CHEMBL272774 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL272336 IC50 = 1300.0 nM 5.89
CHEMBL429734 IC50 = 1800.0 nM 5.75
CHEMBL404646 IC50 = 2100.0 nM 5.68
CHEMBL257517 IC50 = 3200.0 nM 5.50
CHEMBL255389 IC50 = 6200.0 nM 5.21
CHEMBL256468 IC50 = 18100.0 nM 4.74
CHEMBL411118 IC50 = 54000.0 nM 4.27
CHEMBL271240 IC50 > 80000.0 nM -
CHEMBL257891 IC50 - -
CHEMBL272962 IC50 - -
CHEMBL255388 IC50 - -
CHEMBL271739 IC50 - -
CHEMBL403847 IC50 - -
CHEMBL404451 IC50 - -
CHEMBL272963 IC50 - -
CHEMBL272774 IC50 - -