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Assay Detail

CHEMBL933456

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant DPP4 expressed in insect cell
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dipeptidyl peptidase 4 (CHEMBL284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
Edmondson SD, Wei L, Xu J, Shang J, Xu S, Pang J, Chaudhary A, Dean DC, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Scapin G, Wu JK, Beconi MG, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2008) 18 : 2409 -2413
PubMed 18331795 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.31 9.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL402163 1 9.68
CHEMBL445674 1 8.49
CHEMBL257023 1 8.12
CHEMBL404079 1 7.92
CHEMBL376498 1 7.89
CHEMBL437206 1 7.77
CHEMBL375745 1 7.72
CHEMBL1162974 1 7.68
CHEMBL435320 1 7.40
CHEMBL429757 1 7.30
CHEMBL256172 1 7.24
CHEMBL220357 1 7.16
CHEMBL257709 1 7.05
CHEMBL255591 1 7.03
CHEMBL403415 1 6.91
CHEMBL438992 1 6.69
CHEMBL255351 1 6.28
CHEMBL256603 1 6.19
CHEMBL437026 1 5.93
CHEMBL401932 1 5.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL402163 IC50 = 0.21 nM 9.68
CHEMBL445674 IC50 = 3.2 nM 8.49
CHEMBL257023 IC50 = 7.5 nM 8.12
CHEMBL404079 IC50 = 12.0 nM 7.92
CHEMBL376498 IC50 = 13.0 nM 7.89
CHEMBL437206 IC50 = 17.0 nM 7.77
CHEMBL375745 IC50 = 19.0 nM 7.72
CHEMBL1162974 IC50 = 21.0 nM 7.68
CHEMBL435320 IC50 = 40.0 nM 7.40
CHEMBL429757 IC50 = 50.0 nM 7.30
CHEMBL256172 IC50 = 57.0 nM 7.24
CHEMBL220357 IC50 = 70.0 nM 7.16
CHEMBL257709 IC50 = 90.0 nM 7.05
CHEMBL255591 IC50 = 93.0 nM 7.03
CHEMBL403415 IC50 = 122.0 nM 6.91
CHEMBL438992 IC50 = 203.0 nM 6.69
CHEMBL255351 IC50 = 525.0 nM 6.28
CHEMBL256603 IC50 = 645.0 nM 6.19
CHEMBL437026 IC50 = 1165.0 nM 5.93
CHEMBL401932 IC50 = 1490.0 nM 5.83