Assay Detail
Binding
CHEMBL933518
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Displacement of [125I]echistatin from human placental integrin alphaVbeta3 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.89 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.72 |
| CHEMBL408195 | — | — | 1 | 7.46 |
| CHEMBL411941 | CYCLORGDFV | — | 1 | 6.71 |
| CHEMBL265445 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL408195 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL265445 | — | IC50 | = | 2150.0 | nM | 5.67 |