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Assay Detail

CHEMBL933558

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AchE by Ellman's assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M.
Bioorg Med Chem Lett (2008) 18 : 2905 -2909
PubMed 18406135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.79 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL258927 1 8.49
CHEMBL258928 1 8.46
CHEMBL257126 1 8.36
CHEMBL255304 1 8.12
CHEMBL256919 1 8.02
CHEMBL258926 1 7.63
CHEMBL255502 1 7.48
CHEMBL403083 1 7.41
CHEMBL95 TACRINE 4.0 1 7.35
CHEMBL407765 1 7.26
CHEMBL258744 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL258927 IC50 = 3.2 nM 8.49
CHEMBL258928 IC50 = 3.5 nM 8.46
CHEMBL257126 IC50 = 4.4 nM 8.36
CHEMBL255304 IC50 = 7.6 nM 8.12
CHEMBL256919 IC50 = 9.6 nM 8.02
CHEMBL258926 IC50 = 23.6 nM 7.63
CHEMBL255502 IC50 = 33.0 nM 7.48
CHEMBL403083 IC50 = 38.6 nM 7.41
CHEMBL95 TACRINE IC50 = 45.1 nM 7.35
CHEMBL407765 IC50 = 54.8 nM 7.26
CHEMBL258744 IC50 = 69.5 nM 7.16