Assay Detail
Binding
CHEMBL933673
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Inhibition of Bacillus anthracis Enoyl ACP reductase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (CHEMBL1075044) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.46 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 6.30 |
| CHEMBL259629 | — | — | 1 | 6.16 |
| CHEMBL261638 | — | — | 1 | 6.10 |
| CHEMBL260770 | — | — | 1 | 6.10 |
| CHEMBL261348 | — | — | 1 | 5.96 |
| CHEMBL260087 | — | — | 1 | 5.82 |
| CHEMBL260368 | — | — | 1 | 5.82 |
| CHEMBL261420 | — | — | 1 | 5.80 |
| CHEMBL259268 | — | — | 1 | 5.75 |
| CHEMBL403703 | — | — | 1 | 5.57 |
| CHEMBL261109 | — | — | 1 | 5.44 |
| CHEMBL260771 | — | — | 1 | 5.43 |
| CHEMBL265448 | — | — | 1 | 5.17 |
| CHEMBL407894 | — | — | 1 | 5.16 |
| CHEMBL259630 | — | — | 1 | 4.73 |
| CHEMBL259937 | — | — | 1 | 4.67 |
| CHEMBL260652 | — | — | 1 | 4.62 |
| CHEMBL260915 | — | — | 1 | 4.62 |
| CHEMBL261637 | — | — | 1 | 4.55 |
| CHEMBL255941 | — | — | 1 | - |
| CHEMBL406046 | — | — | 1 | - |
| CHEMBL407637 | — | — | 1 | - |
| CHEMBL259486 | — | — | 1 | - |
| CHEMBL260418 | — | — | 1 | - |
| CHEMBL260257 | — | — | 1 | - |
| CHEMBL408939 | — | — | 1 | - |
| CHEMBL262591 | — | — | 1 | - |
| CHEMBL255518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL259629 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL261638 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL260770 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL261348 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL260087 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL260368 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL261420 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL259268 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL403703 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL261109 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL260771 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL265448 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL407894 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL259630 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL259937 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL260652 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL260915 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL261637 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL255941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL406046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL407637 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL259486 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL260418 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL260257 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL408939 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL262591 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL255518 | — | IC50 | > | 100000.0 | nM | - |