Assay Detail
Binding
CHEMBL933708
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Inhibition of PDE3A
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.72 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263642 | — | — | 1 | 7.32 |
| CHEMBL219451 | — | — | 1 | 7.21 |
| CHEMBL260006 | — | — | 1 | 7.11 |
| CHEMBL263641 | — | — | 1 | 6.98 |
| CHEMBL409862 | — | — | 1 | 6.92 |
| CHEMBL408977 | — | — | 1 | 6.85 |
| CHEMBL409651 | — | — | 1 | 6.82 |
| CHEMBL220185 | — | — | 1 | 6.82 |
| CHEMBL375200 | — | — | 1 | 6.79 |
| CHEMBL385754 | — | — | 1 | 6.79 |
| CHEMBL261711 | — | — | 1 | 6.70 |
| CHEMBL219445 | — | — | 1 | 6.68 |
| CHEMBL409613 | — | — | 1 | 6.68 |
| CHEMBL441704 | — | — | 1 | 6.67 |
| CHEMBL259295 | — | — | 1 | 6.65 |
| CHEMBL218855 | — | — | 1 | 6.57 |
| CHEMBL218955 | — | — | 1 | 6.56 |
| CHEMBL410834 | — | — | 1 | 6.55 |
| CHEMBL374993 | — | — | 1 | 6.52 |
| CHEMBL429686 | — | — | 1 | 6.43 |
| CHEMBL387167 | — | — | 1 | 6.14 |
| CHEMBL430071 | — | — | 1 | 6.13 |
| CHEMBL428445 | — | — | 1 | - |
| CHEMBL408978 | — | — | 1 | - |
| CHEMBL409484 | — | — | 1 | - |
| CHEMBL427777 | — | — | 1 | - |
| CHEMBL262088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263642 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL219451 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL260006 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL263641 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL409862 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL408977 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL409651 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL220185 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL375200 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL385754 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL261711 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL219445 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL409613 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL441704 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL259295 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL218855 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL218955 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL410834 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL374993 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL429686 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL387167 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL430071 | — | Ki | = | 739.0 | nM | 6.13 |
| CHEMBL428445 | — | Ki | < | 100.0 | nM | - |
| CHEMBL408978 | — | Ki | < | 100.0 | nM | - |
| CHEMBL409484 | — | Ki | < | 100.0 | nM | - |
| CHEMBL427777 | — | Ki | < | 100.0 | nM | - |
| CHEMBL262088 | — | Ki | < | 100.0 | nM | - |