Assay Detail
Binding
CHEMBL933809
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Binding affinity to HIV1 Nef by isothermal titration calorimetry method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.56 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223235 | — | — | 1 | 6.01 |
| CHEMBL1162107 | — | — | 1 | 5.89 |
| CHEMBL428784 | — | — | 1 | 5.75 |
| CHEMBL259325 | — | — | 1 | 5.17 |
| CHEMBL7644 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223235 | — | Kd | = | 980.0 | nM | 6.01 |
| CHEMBL1162107 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL428784 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL259325 | — | Kd | = | 6700.0 | nM | 5.17 |
| CHEMBL7644 | — | Kd | = | 11000.0 | nM | 4.96 |