Assay Detail
Binding
CHEMBL933817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human SIRT1 expressed in Escherichia coli BL21 by mass spectrometry assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.78 | 6.80 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257991 | — | — | 2 | 6.80 |
| CHEMBL403308 | — | — | 2 | 6.44 |
| CHEMBL254156 | — | — | 2 | 5.54 |
| CHEMBL165 | RESVERATROL | 3.0 | 2 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257991 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL403308 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL254156 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL165 | RESVERATROL | EC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL165 | RESVERATROL | Activity | = | 201.0 | % | - |
| CHEMBL254156 | — | Activity | = | 447.0 | % | - |
| CHEMBL403308 | — | Activity | = | 296.0 | % | - |
| CHEMBL257991 | — | Activity | = | 781.0 | % | - |