Assay Detail
Binding
CHEMBL933853
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Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor by solid phase assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.94 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269913 | — | — | 1 | 9.59 |
| CHEMBL437072 | — | — | 1 | 8.55 |
| CHEMBL411863 | — | — | 1 | 8.36 |
| CHEMBL406912 | — | — | 1 | 8.29 |
| CHEMBL392303 | — | — | 1 | 8.25 |
| CHEMBL410050 | — | — | 1 | 8.25 |
| CHEMBL270690 | — | — | 1 | 8.15 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.72 |
| CHEMBL270683 | — | — | 1 | 7.12 |
| CHEMBL406680 | — | — | 1 | 6.76 |
| CHEMBL2372171 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269913 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL437072 | — | IC50 | = | 2.84 | nM | 8.55 |
| CHEMBL411863 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL406912 | — | IC50 | = | 5.15 | nM | 8.29 |
| CHEMBL392303 | — | IC50 | = | 5.64 | nM | 8.25 |
| CHEMBL410050 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL270690 | — | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL270683 | — | IC50 | = | 75.14 | nM | 7.12 |
| CHEMBL406680 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL2372171 | — | IC50 | = | 530.0 | nM | 6.28 |