Assay Detail
Binding
CHEMBL933864
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Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor low affinity state by solid phase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.49 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411863 | — | — | 1 | 7.62 |
| CHEMBL437072 | — | — | 1 | 6.75 |
| CHEMBL410050 | — | — | 1 | 6.60 |
| CHEMBL406680 | — | — | 1 | 6.49 |
| CHEMBL270690 | — | — | 1 | 6.26 |
| CHEMBL406912 | — | — | 1 | 6.22 |
| CHEMBL2372171 | — | — | 1 | 6.08 |
| CHEMBL270683 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411863 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL437072 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL410050 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL406680 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL270690 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL406912 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2372171 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL270683 | — | IC50 | = | 1350.0 | nM | 5.87 |