Assay Detail
Binding
CHEMBL934086
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Activity at L type calcium channel in K+ depolarized guinea pig longitudinal smooth muscle assessed as inhibition of calcium induced contraction
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.13 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.82 |
| CHEMBL271355 | — | — | 1 | 7.26 |
| CHEMBL411235 | — | — | 1 | 7.08 |
| CHEMBL439315 | — | — | 1 | 6.62 |
| CHEMBL405876 | — | — | 1 | 6.26 |
| CHEMBL272471 | — | — | 1 | 5.78 |
| CHEMBL409148 | — | — | 1 | 5.71 |
| CHEMBL271964 | — | — | 1 | 5.69 |
| CHEMBL271993 | — | — | 1 | 5.59 |
| CHEMBL271994 | — | — | 1 | 4.96 |
| CHEMBL438024 | — | — | 1 | 4.91 |
| CHEMBL412260 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL271355 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL411235 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL439315 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL405876 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL272471 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL409148 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL271964 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL271993 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL271994 | — | IC50 | = | 11040.0 | nM | 4.96 |
| CHEMBL438024 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL412260 | — | IC50 | = | 12810.0 | nM | 4.89 |