Assay Detail
Binding
CHEMBL934096
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Inhibition of 11beta-HSD1
70
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 7.51 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370362 | — | — | 1 | 8.72 |
| CHEMBL383352 | — | — | 1 | 8.70 |
| CHEMBL373257 | — | — | 1 | 8.70 |
| CHEMBL372851 | — | — | 1 | 8.59 |
| CHEMBL197489 | — | — | 1 | 8.40 |
| CHEMBL426835 | — | — | 1 | 8.39 |
| CHEMBL198849 | — | — | 1 | 8.38 |
| CHEMBL403283 | — | — | 1 | 8.33 |
| CHEMBL197220 | — | — | 1 | 8.31 |
| CHEMBL429655 | — | — | 1 | 8.30 |
| CHEMBL219448 | — | — | 1 | 8.30 |
| CHEMBL407945 | — | — | 1 | 8.30 |
| CHEMBL402046 | — | — | 1 | 8.30 |
| CHEMBL257059 | — | — | 1 | 8.28 |
| CHEMBL245851 | — | — | 1 | 8.22 |
| CHEMBL257011 | — | — | 1 | 8.22 |
| CHEMBL394884 | — | — | 1 | 8.22 |
| CHEMBL372945 | — | — | 1 | 8.14 |
| CHEMBL246047 | — | — | 1 | 8.10 |
| CHEMBL373034 | — | — | 1 | 8.07 |
| CHEMBL246676 | — | — | 1 | 8.05 |
| CHEMBL271211 | — | — | 1 | 8.03 |
| CHEMBL198690 | — | — | 1 | 8.01 |
| CHEMBL404185 | — | — | 1 | 8.00 |
| CHEMBL246678 | — | — | 1 | 7.96 |
| CHEMBL270185 | — | — | 1 | 7.96 |
| CHEMBL401923 | — | — | 1 | 7.96 |
| CHEMBL397074 | — | — | 1 | 7.92 |
| CHEMBL219606 | — | — | 1 | 7.89 |
| CHEMBL403215 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370362 | — | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL383352 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL373257 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL372851 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL197489 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL426835 | — | IC50 | = | 4.074 | nM | 8.39 |
| CHEMBL198849 | — | IC50 | = | 4.169 | nM | 8.38 |
| CHEMBL403283 | — | IC50 | = | 4.677 | nM | 8.33 |
| CHEMBL197220 | — | IC50 | = | 4.898 | nM | 8.31 |
| CHEMBL429655 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL219448 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL407945 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL402046 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL257059 | — | IC50 | = | 5.248 | nM | 8.28 |
| CHEMBL394884 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL257011 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL245851 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL372945 | — | IC50 | = | 7.244 | nM | 8.14 |
| CHEMBL246047 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL373034 | — | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL246676 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL271211 | — | IC50 | = | 9.333 | nM | 8.03 |
| CHEMBL198690 | — | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL404185 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL401923 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL270185 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL246678 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL397074 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL219606 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL403215 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL257010 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL245647 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL3085038 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL246057 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL371262 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL255148 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL402558 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL555375 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL218247 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL376272 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL404399 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL256800 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL429501 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL270423 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL247286 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL272996 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL374409 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL269973 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL402545 | — | IC50 | = | 44.67 | nM | 7.35 |
| CHEMBL404703 | — | IC50 | = | 46.77 | nM | 7.33 |