Assay Detail
Binding
CHEMBL934223
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Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel Cav1.2b in rabbit expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.64 | 8.84 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271355 | — | — | 1 | 8.84 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.44 |
| CHEMBL272472 | — | — | 1 | - |
| CHEMBL439315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271355 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL272472 | — | Activity | - | — | - | |
| CHEMBL439315 | — | Activity | - | — | - |