Assay Detail
Functional
CHEMBL934286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human delta opioid receptor by [35S]GTP-gamma-S binding assay
24
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 8 | - | - |
| EC50 | 8 | 7.61 | 8.96 |
| logEC50 | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 3 | 8.96 |
| CHEMBL31421 | — | — | 3 | 8.80 |
| CHEMBL271619 | — | — | 3 | 7.77 |
| CHEMBL261390 | — | — | 3 | 7.46 |
| CHEMBL438389 | — | — | 3 | 7.10 |
| CHEMBL261608 | — | — | 3 | 7.07 |
| CHEMBL406030 | — | — | 3 | 6.92 |
| CHEMBL272665 | — | — | 3 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL31421 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL271619 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL261390 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL438389 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL261608 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL406030 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL272665 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL261390 | — | Emax | = | 16.0 | % | - |
| CHEMBL31421 | — | logEC50 | = | -8.8 | — | - |
| CHEMBL406030 | — | Emax | = | 137.0 | % | - |
| CHEMBL406030 | — | logEC50 | = | -6.9 | — | - |
| CHEMBL438389 | — | Emax | = | 161.0 | % | - |
| CHEMBL438389 | — | logEC50 | = | -7.1 | — | - |
| CHEMBL31421 | — | Emax | = | 69.0 | % | - |
| CHEMBL261390 | — | logEC50 | = | -7.5 | — | - |
| CHEMBL272665 | — | logEC50 | = | -6.8 | — | - |
| CHEMBL271619 | — | Emax | = | 56.0 | % | - |
| CHEMBL271619 | — | logEC50 | = | -7.8 | — | - |
| CHEMBL200199 | BIPHALIN | logEC50 | = | -9.0 | — | - |
| CHEMBL261608 | — | Emax | = | 131.0 | % | - |
| CHEMBL261608 | — | logEC50 | = | -7.1 | — | - |
| CHEMBL200199 | BIPHALIN | Emax | = | 83.0 | % | - |
| CHEMBL272665 | — | Emax | = | 70.0 | % | - |