Assay Detail

CHEMBL934293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of microtubule-activated Eg5 ATPase activity

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Kinesin-like protein KIF11 (CHEMBL4581) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Kinesin-like protein KIF11 (CHEMBL4581) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Kinesin-like protein KIF11

CHEMBL4581

Anchored from Assay target.

Protein identity Kinesin-like protein KIF11

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Kinesin-like protein KIF11 (CHEMBL4581) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F.
J Med Chem (2008) 51 : 1115 -1125
PubMed 18266314 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.85	6.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL392695	S-TRITYL-L-CYSTEINE	—	1	6.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL392695	S-TRITYL-L-CYSTEINE	IC50	=	140.0	nM	6.85