Assay Detail
Binding
CHEMBL934304
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Inhibition of transketolase by TPPK/apo-TK coupled assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 25 | 7.27 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255603 | — | — | 1 | 8.15 |
| CHEMBL256627 | — | — | 1 | 8.00 |
| CHEMBL256831 | — | — | 1 | 7.64 |
| CHEMBL402329 | — | — | 1 | 7.60 |
| CHEMBL402566 | — | — | 1 | 7.60 |
| CHEMBL255340 | — | — | 1 | 7.57 |
| CHEMBL258077 | — | — | 1 | 7.55 |
| CHEMBL256454 | — | — | 1 | 7.54 |
| CHEMBL252086 | — | — | 1 | 7.48 |
| CHEMBL271044 | — | — | 1 | 7.47 |
| CHEMBL270632 | — | — | 1 | 7.44 |
| CHEMBL403365 | — | — | 1 | 7.44 |
| CHEMBL255541 | — | — | 1 | 7.40 |
| CHEMBL270613 | — | — | 1 | 7.34 |
| CHEMBL255542 | — | — | 1 | 7.28 |
| CHEMBL429246 | — | — | 1 | 7.24 |
| CHEMBL271521 | — | — | 1 | 7.19 |
| CHEMBL403212 | — | — | 1 | 7.12 |
| CHEMBL270168 | — | — | 1 | 6.98 |
| CHEMBL270384 | — | — | 1 | 6.96 |
| CHEMBL255339 | — | — | 1 | 6.92 |
| CHEMBL402065 | — | — | 1 | 6.85 |
| CHEMBL256267 | — | — | 1 | 6.66 |
| CHEMBL257929 | — | — | 1 | 6.51 |
| CHEMBL270385 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255603 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL256627 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL256831 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL402329 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL402566 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL255340 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL258077 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL256454 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL252086 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL271044 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL270632 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL403365 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL255541 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL270613 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL255542 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL429246 | — | Kd | = | 57.0 | nM | 7.24 |
| CHEMBL271521 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL403212 | — | Kd | = | 75.0 | nM | 7.12 |
| CHEMBL270168 | — | Kd | = | 104.0 | nM | 6.98 |
| CHEMBL270384 | — | Kd | = | 109.0 | nM | 6.96 |
| CHEMBL255339 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL402065 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL256267 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL257929 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL270385 | — | Kd | = | 1460.0 | nM | 5.84 |