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Assay Detail

CHEMBL934464

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Binding
Inhibition of CaMK2delta
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Publication

Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 1: SAR of the aryl region.
Levy DE, Wang DX, Lu Q, Chen Z, Perumattam J, Xu YJ, Liclican A, Higaki J, Dong H, Laney M, Mavunkel B, Dugar S.
Bioorg Med Chem Lett (2008) 18 : 2390 -2394
PubMed 18334294 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 6.00 7.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL403446 1 7.47
CHEMBL412302 1 6.75
CHEMBL408434 1 6.55
CHEMBL411253 1 6.54
CHEMBL269264 1 6.51
CHEMBL258290 1 6.44
CHEMBL270875 1 6.42
CHEMBL409834 1 6.30
CHEMBL407464 1 6.27
CHEMBL402775 1 6.20
CHEMBL256265 1 6.12
CHEMBL407666 1 5.92
CHEMBL409232 1 5.88
CHEMBL256827 1 5.87
CHEMBL410536 1 5.83
CHEMBL270662 1 5.80
CHEMBL272295 1 5.80
CHEMBL403887 1 5.78
CHEMBL427724 1 5.63
CHEMBL256259 1 5.42
CHEMBL446110 1 5.34
CHEMBL257851 1 5.12
CHEMBL411456 1 5.12
CHEMBL402591 1 4.82
CHEMBL255178 1 -
CHEMBL408462 1 -
CHEMBL402774 1 -
CHEMBL404438 1 -
CHEMBL402013 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL403446 IC50 = 34.0 nM 7.47
CHEMBL412302 IC50 = 180.0 nM 6.75
CHEMBL408434 IC50 = 280.0 nM 6.55
CHEMBL411253 IC50 = 290.0 nM 6.54
CHEMBL269264 IC50 = 310.0 nM 6.51
CHEMBL258290 IC50 = 360.0 nM 6.44
CHEMBL270875 IC50 = 380.0 nM 6.42
CHEMBL409834 IC50 = 500.0 nM 6.30
CHEMBL407464 IC50 = 540.0 nM 6.27
CHEMBL402775 IC50 = 630.0 nM 6.20
CHEMBL256265 IC50 = 750.0 nM 6.12
CHEMBL407666 IC50 = 1190.0 nM 5.92
CHEMBL409232 IC50 = 1320.0 nM 5.88
CHEMBL256827 IC50 = 1350.0 nM 5.87
CHEMBL410536 IC50 = 1490.0 nM 5.83
CHEMBL270662 IC50 = 1580.0 nM 5.80
CHEMBL272295 IC50 = 1600.0 nM 5.80
CHEMBL403887 IC50 = 1680.0 nM 5.78
CHEMBL427724 IC50 = 2320.0 nM 5.63
CHEMBL256259 IC50 = 3810.0 nM 5.42
CHEMBL446110 IC50 = 4560.0 nM 5.34
CHEMBL257851 IC50 = 7610.0 nM 5.12
CHEMBL411456 IC50 = 7540.0 nM 5.12
CHEMBL402591 IC50 = 15020.0 nM 4.82
CHEMBL255178 IC50 > 20000.0 nM -
CHEMBL408462 IC50 > 20000.0 nM -
CHEMBL402774 IC50 > 20000.0 nM -
CHEMBL404438 IC50 > 20000.0 nM -
CHEMBL402013 IC50 > 20000.0 nM -