Assay Detail
Binding
CHEMBL934520
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Displacement of [3H]spiperone from cloned human dopamine D3 receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.69 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411437 | — | — | 1 | 6.50 |
| CHEMBL272395 | — | — | 1 | 6.39 |
| CHEMBL270056 | — | — | 1 | 6.23 |
| CHEMBL405260 | — | — | 1 | 6.03 |
| CHEMBL272396 | — | — | 1 | 6.03 |
| CHEMBL272602 | — | — | 1 | 5.66 |
| CHEMBL407818 | — | — | 1 | 5.47 |
| CHEMBL405292 | — | — | 1 | 5.47 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.35 |
| CHEMBL310843 | — | — | 1 | 5.28 |
| CHEMBL272873 | — | — | 1 | 5.06 |
| CHEMBL272853 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411437 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL272395 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL270056 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL405260 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL272396 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL272602 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL407818 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL405292 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL7927 | FAUC 113 | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL310843 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL272873 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL272853 | — | Ki | = | 15000.0 | nM | 4.82 |