Assay Detail
Binding
CHEMBL934601
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Inhibition of aromatase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.90 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67842 | — | — | 1 | 7.16 |
| CHEMBL201831 | — | — | 1 | 7.00 |
| CHEMBL3084324 | — | — | 1 | 6.80 |
| CHEMBL225472 | — | — | 1 | 6.55 |
| CHEMBL53068 | — | — | 1 | 5.82 |
| CHEMBL438549 | — | — | 1 | 5.80 |
| CHEMBL24593 | — | — | 1 | 5.62 |
| CHEMBL195571 | — | — | 1 | 5.57 |
| CHEMBL225447 | — | — | 1 | 5.55 |
| CHEMBL195996 | — | — | 1 | 5.55 |
| CHEMBL157925 | — | — | 1 | 5.43 |
| CHEMBL65590 | — | — | 1 | 5.30 |
| CHEMBL298720 | — | — | 1 | 5.27 |
| CHEMBL206300 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67842 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL201831 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3084324 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL225472 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL53068 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL438549 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL24593 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL195571 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL225447 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL195996 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL157925 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL65590 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL298720 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL206300 | — | IC50 | = | 5700.0 | nM | 5.24 |