Assay Detail
Functional
CHEMBL934612
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Inhibition of LPS-induced TNFalpha production in human PBMC
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.00 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259922 | — | — | 1 | 8.22 |
| CHEMBL265710 | — | — | 1 | 7.80 |
| CHEMBL259007 | — | — | 1 | 7.72 |
| CHEMBL429863 | — | — | 1 | 7.57 |
| CHEMBL409916 | — | — | 1 | 7.44 |
| CHEMBL260807 | — | — | 1 | 7.37 |
| CHEMBL409328 | — | — | 1 | 7.30 |
| CHEMBL409329 | — | — | 1 | 7.30 |
| CHEMBL410136 | — | — | 1 | 7.19 |
| CHEMBL410668 | — | — | 1 | 7.17 |
| CHEMBL261021 | — | — | 1 | 6.71 |
| CHEMBL259212 | — | — | 1 | 6.66 |
| CHEMBL440406 | — | — | 1 | 6.54 |
| CHEMBL258851 | — | — | 1 | 6.54 |
| CHEMBL412281 | — | — | 1 | 6.29 |
| CHEMBL439267 | — | — | 1 | 6.20 |
| CHEMBL258653 | — | — | 1 | 6.10 |
| CHEMBL261235 | — | — | 1 | 5.83 |
| CHEMBL407046 | — | — | 1 | - |
| CHEMBL261075 | — | — | 1 | - |
| CHEMBL412265 | — | — | 1 | - |
| CHEMBL260134 | — | — | 1 | - |
| CHEMBL410667 | — | — | 1 | - |
| CHEMBL258974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259922 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL265710 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL259007 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL429863 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL409916 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL260807 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL409328 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL409329 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL410136 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL410668 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL261021 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL259212 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL440406 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL258851 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL412281 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL439267 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL258653 | — | IC50 | = | 801.0 | nM | 6.10 |
| CHEMBL261235 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL407046 | — | IC50 | > | 250.0 | nM | - |
| CHEMBL261075 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL412265 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL260134 | — | IC50 | > | 250.0 | nM | - |
| CHEMBL410667 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL258974 | — | IC50 | < | 8.0 | nM | - |