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Assay Detail

CHEMBL934768

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Binding
Inhibition of ACE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26.
Ntai I, Bachmann BO.
Bioorg Med Chem Lett (2008) 18 : 3068 -3071
PubMed 18096385 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.40 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1560 CAPTOPRIL 4.0 1 8.11
CHEMBL265206 1 7.84
CHEMBL265205 1 6.86
CHEMBL259594 1 6.63
CHEMBL259593 1 4.68
CHEMBL411656 1 4.26
CHEMBL259123 1 -
CHEMBL258914 1 -
CHEMBL264695 1 -
CHEMBL264962 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1560 CAPTOPRIL IC50 = 7.7 nM 8.11
CHEMBL265206 IC50 = 14.4 nM 7.84
CHEMBL265205 IC50 = 139.0 nM 6.86
CHEMBL259594 IC50 = 234.3 nM 6.63
CHEMBL259593 IC50 = 21000.0 nM 4.68
CHEMBL411656 IC50 = 54600.0 nM 4.26
CHEMBL259123 IC50 > 1000000.0 nM -
CHEMBL258914 IC50 = 236000.0 nM -
CHEMBL264695 IC50 = 2000000.0 nM -
CHEMBL264962 IC50 = 3.83e-05 nM -