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Assay Detail

CHEMBL934813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human 11-beta-HSD1 by SPA assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Zhu Y, Olson SH, Graham D, Patel G, Hermanowski-Vosatka A, Mundt S, Shah K, Springer M, Thieringer R, Wright S, Xiao J, Zokian H, Dragovic J, Balkovec JM.
Bioorg Med Chem Lett (2008) 18 : 3412 -3416
PubMed 18440812 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 8.38 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL258447 1 9.00
CHEMBL256720 1 9.00
CHEMBL256291 1 9.00
CHEMBL257149 1 9.00
CHEMBL404436 1 9.00
CHEMBL402552 1 9.00
CHEMBL402386 1 8.70
CHEMBL403993 1 8.70
CHEMBL258446 1 8.70
CHEMBL403201 1 8.70
CHEMBL257148 1 8.70
CHEMBL255660 1 8.70
CHEMBL256515 1 8.70
CHEMBL404435 1 8.70
CHEMBL255936 1 8.70
CHEMBL256514 1 8.52
CHEMBL404095 1 8.30
CHEMBL258448 1 8.30
CHEMBL256777 1 8.11
CHEMBL402613 1 8.10
CHEMBL402995 1 8.10
CHEMBL255934 1 8.00
CHEMBL256571 1 7.89
CHEMBL256090 1 7.82
CHEMBL255259 1 7.66
CHEMBL402387 1 7.57
CHEMBL256292 1 7.50
CHEMBL255260 1 7.46
CHEMBL257414 1 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL258447 IC50 = 1.0 nM 9.00
CHEMBL256720 IC50 = 1.0 nM 9.00
CHEMBL256291 IC50 = 1.0 nM 9.00
CHEMBL257149 IC50 = 1.0 nM 9.00
CHEMBL404436 IC50 = 1.0 nM 9.00
CHEMBL402552 IC50 = 1.0 nM 9.00
CHEMBL402386 IC50 = 2.0 nM 8.70
CHEMBL403993 IC50 = 2.0 nM 8.70
CHEMBL258446 IC50 = 2.0 nM 8.70
CHEMBL403201 IC50 = 2.0 nM 8.70
CHEMBL257148 IC50 = 2.0 nM 8.70
CHEMBL255660 IC50 = 2.0 nM 8.70
CHEMBL256515 IC50 = 2.0 nM 8.70
CHEMBL404435 IC50 = 2.0 nM 8.70
CHEMBL255936 IC50 = 2.0 nM 8.70
CHEMBL256514 IC50 = 3.0 nM 8.52
CHEMBL404095 IC50 = 5.0 nM 8.30
CHEMBL258448 IC50 = 5.0 nM 8.30
CHEMBL256777 IC50 = 7.8 nM 8.11
CHEMBL402613 IC50 = 8.0 nM 8.10
CHEMBL402995 IC50 = 8.0 nM 8.10
CHEMBL255934 IC50 = 10.0 nM 8.00
CHEMBL256571 IC50 = 13.0 nM 7.89
CHEMBL256090 IC50 = 15.0 nM 7.82
CHEMBL255259 IC50 = 22.0 nM 7.66
CHEMBL402387 IC50 = 27.0 nM 7.57
CHEMBL256292 IC50 = 32.0 nM 7.50
CHEMBL255260 IC50 = 35.0 nM 7.46
CHEMBL257414 IC50 = 43.0 nM 7.37